Beckham Lab
Publications

Publications

A full list of the group's work. For the most current record, see Google Scholar.

2022
Microbiology 168(7)

Crystal structures of WrbA, a spurious target of the salicylidene acylhydrazide inhibitors of type III secretion in Gram-negative pathogens, and verification of improved specificity of next-generation compounds

Zambelloni R, Beckham KSH, Wu HJ, Elofsson M, Marquez R, Gabrielsen M, Roe AJ

2022
PNAS Nexus 1(4), pgac130

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus

Paulowski L, Beckham KSH, Johansen MD, et al.

2021
Science Advances 7(26), eabg9923

Structure of the mycobacterial ESX-5 type VII secretion system pore complex

Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M

2021
Microbiology 167(7), 001054

Conserved and specialized functions of Type VII secretion systems in non-tuberculous mycobacteria

Lagune M, Petit C, Sotomayor FV, Johansen MD, Beckham KSH, Ritter C, Girard Misguich F, Wilmanns M, Kremer L, Maurer FP, Herrmann JL

2020
Protein Science

The pMy vector series: a versatile cloning platform for the recombinant production of mycobacterial proteins in Mycobacterium smegmatis

Beckham KSH, Staack S, Wilmanns M, Parret AHA

2020
Progress in Biophysics and Molecular Biology

The ATPases of the mycobacterial type VII secretion system: structural and mechanistic insights into secretion

Crosskey TD, Beckham KSH, Wilmanns M

2019
Molecular Cell

An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death

Freire DM, Gutierrez C, Garza-Garcia A, et al. (incl. Beckham KSH)

2017
Nature Microbiology

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis

Beckham KSH, Ciccarelli L, Bunduc CM, Mertens HDT, Ummels R, Lugmayr W, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC, Parret AHA, Houben ENG

2014
Molecular Microbiology 93(1), 199–211

The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7

Beckham KSH, Connolly JPR, Ritchie JM, Wang D, Gawthorne JA, Tahoun A, Gally DL, Burgess K, Burchmore RJ, Smith BO, Beatson SA, Byron O, Wolfe AJ, Douce GR, Roe AJ

2014
European Journal of Immunology

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103+CD11b+ DCs in the intestinal lamina propria

Scott CL, Zangerle Murray TFP, Beckham KSH, Douce G, Mowat AM

2014
Frontiers in Cellular and Infection Microbiology

From screen to target: insights and approaches for the development of anti-virulence compounds

Beckham KSH, Roe AJ

2012
PLoS ONE

Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification

Gawthorne JA, Reddick LE, Akpunarlieva SN, Beckham KSH, Christie JM, Alto NM

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